Adith Arun

About

I am currently in medical school at Yale, where I just finished my third year. I work on health outcomes research (with Harlan Krumholz) and cancer genomics.

I am interested in digital health, precision medicine, and leveraging AI to solve problems in medicine and healthcare. I like thinking critically about medical research, clinical trials, biotech companies, and statistics. I write about these things on my Substack.

Previously, I worked at Delfi Diagnostics as a data scientist to develop new approaches for detecting cancer early and monitoring response to treatment using cell-free DNA fragmentation patterns.

From 2018 to 2021, I was an undergraduate at Johns Hopkins where I majored in applied math and studied the origins of cell-free DNA and genomic features for cancer early detection in the Velculescu Lab. I spent my summers during this time at IBM Research working to develop new ensemble learning algorithms and models for identifying synergistic drug combinations.

Papers

Please see my Google Scholar for the most updated list

1. Yan BW, Arun AS, Curtis LH, Kadakia KT, Lin Z, Lu Y, Wadhera R, Kumholz HM, Dhriva SS. Cardiovascular Disease Mortality Trends in the United States (1999-2023). Journal of the American College of Cardiology, 2025. (link)
   
   Media:

   • How Have CVD Mortality Trends Changed?(American College of Cardiology Latest In Cardiology)
   • UCSF Study: Cardiovascular deaths in the U.S. reach record highs in 2023(Fox San Francisco)
2. Arun AS, Durant TJS, El-Khoury JM, Krumholz HM. Reevaluating the Threshold for Low Total Testosterone. Clinical Chemistry, 2025. (link)
   
   Media:

   • Reevaluating the threshold for low total testosterone (Association for Diagnostics and Lab Medicine Clinical Chemistry Podcast); Spotify Link
3. Arun AS, Liarakos D, Mendiratta G, Kim J, Goshua G, Olson P, Stites ES. Integrating Epidemiology and Genomics Data to Estimate the Prevalence of Acquired Cysteine Drug Targets in the US Cancer Patient Population. The Pharmacogenomics Journal, 2025. (link)
4. Sawano M, Wu Y, Shah RM, Zhou T, Arun AS, ... , Iwasaki A, Krumholz HM. Long COVID Characteristics and Experience: A Descriptive Study from the Yale LISTEN Research Cohort. American Journal of Medicine, 2025.(link)
5. Arun AS, Shah R, Lu Y, Baldassarri SR, Krumholz HM. Evaluating cotinine cutoffs and sociodemographic factors associated with exclusive heavy e-cigarette vaping behavior. medRxiv, 2025. (preprint)
6. Arun AS, Krumholz HM. Yearly Trends in Cause Specific Age-Adjusted Mortality from 1999-2020 in Black and White Non-Hispanic Americans. medRxiv, 2024.(preprint)
7. Arun AS, Caraballo C, Swano M, Lu Y, Khera R, Yancy CW, Krumholz HM. Cause-specific Mortality Rates Among the US Black Population. JAMA Network Open, 2024. (link)
   
   Media:

   • Black Americans Are Still More Likely to Die Early Than Their White Peers (Everyday Health)
8. Arun AS, Sawano M, Lu Y, Warner F, Caraballo C, Khera R, Echols MR, Yancy CW, Krumholz HM. Excess Cardiovascular Mortality Among Black Americans 2000-2022. Journal of the American College of Cardiology, 2024.(link)
   
   Media:

   • JACC Report Card Documents Excess CV Mortality Among Black Americans (American College of Cardiology)
   • 1.6 million excess Black deaths owed to inequities in cardiac care, JACC report card reveals (Cardiovascular Business)
   • Despite Gains, Black Americans Still Face Higher CV Mortality (TCT MD)
9. Arun AS, Yue JJ, Khachane VB, Sumpio B, Tonnessen B. Endovascular Stenting of External Iliac Vein Injury During Anterior Spine Exposure. Journal of Vascular Surgery Cases, Innovations, and Techniques, 2024. (link)
10. Zhou T, Sawano M, Arun AS, Caraballo C, ... , Herrin J, Iwasaki A, Krumholz HM. Internal Tremors and Vibrations in Long COVID: a Cross-Sectional Study. American Journal of Medicine, 2024. (link)
    
    Media:

    • Internal Tremors: Adding to the List of Long COVID Symptoms (Yale Medicine News)
11. Arun AS, Kim SC, Ahsen ME, Stolovitzky G. Modeling Combination Therapies In Patient Cohorts and Cell Cultures Using Correlated Drug Action. iScience, 2024. (link)
12. Elzamzami FD, Samal A, Arun AS, Dharmaraj T, ... , Cole RN, Wilson KL. Native Lamin A/C Proteomes and Novel Partners from Heart and Skeletal Muscle in a Mouse Chronic Inflammation Model of Human Frailty. Frontiers in Cell and Developmental Biology, 2023. (link)
13. Erve I, Medina JE, Leal A, Papp E, Phallen J, Adleff V, Chiao EJ, Arun AS, ... , Velculescu VE, Fijneman RJA. Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequenced of Cell-Free DNA and Matched White Blood Cells, 2023. (link)
14. Kim SC, Arun AS, Ahsen ME, Vogel R, Stolovitzky G. The Fermi-Dirac Distribution Provides a Calibrated Probabilistic Output for Binary Classifiers. PNAS, 2021. (link)
15. Mathios D, Johansen JS, Cristiano S, Median JE, Phallen J, Larsen KR, Bruhm DC, Niknafs N, Ferreira L, Adleff V, Chiao JY, Leal A, Noe M, White JR, Arun AS, ... , Scharpf RB, Velculescu VE. Detection and Characterization of Lung Cancer Using cell-free DNA Fragmentomes, 2021. (link)
    
    Media:

    • Delfi Diagnostics' AI-based blood test detects 80% of early-stage lung cancer cases, study finds (Fierce Biotech)
    • Novel AI blood testing technology can ID lung cancers with high accuracy (ScienceDaily)
    • Novel AI Blood Testing Technology Can ID Lung Cancers with High Accuracy (Johns Hopkins Medicine)
16. Arun AS, Eddings CR, Wilson KL. Novel Missense Alleles of SIGMAR1 as Tools to Understand Emerin-Dependent Gene Silencing in Response to Cocaine. Experimental Biology and Medicine, 2019. (link)
17. Arun AS, Tepper CG, Lam KS. Identification of Integrin Drug Targets for 17 Solid Tumor Types. Oncotarget, 2018. (link)

Selected Posters

1. Mouslmani MAL, Sawano M, Arun AS, ..., Krumholz HM. Characterization of Postural Orthostatic Tachycardia Syndrome in Long COVID: A Cross-Sectional Study and a Machine Learning Model. Journal of the American College of Cardiology, 2025. (link)
2. Arun AS, Medina JE, Cristiano S, Bruhm DC, Fijneman RJ, Meijer GA, Leal A, Velculescu VE, Scharpf RB. PLASMUT: an R Package for Estimating the Probability of Tumor-Specific Mutations in cell-free DNA. American Association for Cancer Research, 2024. (link, BioConductor package, vignette)
3. Lu Y, Arun AS, Khosla P, ... , Mouslmani MAL, Krumholz HM. Hypertension Excess Mortality and Years of Potential Life Lost in Black Americans. Journal of the American College of Cardiology, 2024. (link)
4. Erve I, Medina JE, Leal A, Papp E, Phallen J, Adleff V, Chiao EJ, Arun AS, ... , Velculescu VE, Fijneman RJ. Ultra-Deep Targeted Sequencing of cell-free DNA and Patient-Matched White Blood Cells for Treatment Response Evaluation in Patients with Metastatic Colorectal Cancer. American Association for Cancer Research, 2023. (link)

News and Views

1. Arun AS. Visualizing Publication Trends for Scientists. Yale Journal of Biology and Medicine 2023 Issue on Big Data, 2023. (link)